At noon conference on 11/4/19 we presented a patient with menorrhagia and bruising concerning for primary homeostasis problem (=PLATELETS). We discussed different symptoms of primary vs secondary homeostasis. She was diagnosed with Acute Promyelocytic Leukemia and treated with ATRA and Arsenic Trioxide (ATO).
Take home points:
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Identify differences in presentation of thrombocytopenia versus coagulation disorders
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Recognize causes of thrombocytopenia
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Acute leukemias usually present with symptoms of pancytopenia
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APL is distinct amongst leukemias in pathophysiology and treatment
APL – 11.4
