At noon conference on 11/4/19 we presented a patient with menorrhagia and bruising concerning for primary homeostasis problem (=PLATELETS). We discussed different symptoms of primary vs secondary homeostasis. She was diagnosed with Acute Promyelocytic Leukemia and treated with ATRA and Arsenic Trioxide (ATO).

Take home points:

  • Identify differences in presentation of thrombocytopenia versus coagulation disorders

  • Recognize causes of thrombocytopenia

  • Acute leukemias usually present with symptoms of pancytopenia

  • APL is distinct amongst leukemias in pathophysiology and treatment

APL – 11.4